$0 in pending offers
(See the safety review section, "How might this disrupt the microbiome", subheading, "In the gut"
Oh, the odds of it successfully colonizing the gut seem very low to me. Humans are constantly swallowing wild S mutans without issue, so I don't expect it to gain a foothold on its own. The mutacin 1140 could be an issue, but mutacin isn't very stable through the stomach acid, and the half-life/pharmokinetics are pretty bad; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256755/.
BCS3L1 contains JH1140's knockouts for genetic stability, too, so I expect it to mutate much less than standard S mutans. A year of rat testing didn't indicate disruption to their gut microbiota.
Additionally, the people who self-colonized with strains like JH1005 haven't reported any issue ¯\_(ツ)_/¯
If everyone on earth colonized with this, I suppose I do expect someone to get autobrewery, because multiplying a very small number by a very big number does yield a number, but I don't expect to see that failure state in the first million people.
Technically speaking, it probably does raise the risk some, but I don't actually predict it to be a problem; see the Safety Review section "Will I get drunk?"
I think our odds are very good. I'm working with the original inventors, Drs. Hillman and Smith, who made it the first time.
I'm not sure that I can link to my Lightspeed application? The link they sent me is an edit link, and I don't want to post that on the public internet.