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Aaron Silverbook

@AaronSilverbook

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Aaron Silverbook

5 months ago

BCS3L1 secretes 0.032 grams of ethanol over 24 hours. A shot of vodka is about 12 grams of ethanol.

I strongly doubt it'll make anyone fail a breathalyzer, but I'll let you know once I've put it in my mouth.

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Aaron Silverbook

5 months ago

@7b7599c6-0cb1-4473-8d5b-d4687cc16b39

Oh, the odds of it successfully colonizing the gut seem very low to me. Humans are constantly swallowing wild S mutans without issue, so I don't expect it to gain a foothold on its own. The mutacin 1140 could be an issue, but mutacin isn't very stable through the stomach acid, and the half-life/pharmokinetics are pretty bad; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256755/.

BCS3L1 contains JH1140's knockouts for genetic stability, too, so I expect it to mutate much less than standard S mutans. A year of rat testing didn't indicate disruption to their gut microbiota.

Additionally, the people who self-colonized with strains like JH1005 haven't reported any issue ¯\_(ツ)_/¯

If everyone on earth colonized with this, I suppose I do expect someone to get autobrewery, because multiplying a very small number by a very big number does yield a number, but I don't expect to see that failure state in the first million people.

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Aaron Silverbook

5 months ago

Technically speaking, it probably does raise the risk some, but I don't actually predict it to be a problem; see the Safety Review section "Will I get drunk?"

https://docs.google.com/document/d/1mDJCTO2QySmQOZQcajYReDCA1MFpKs-EZ5E0VNu50Fo/edit#heading=h.ksdlksmy4wor

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Aaron Silverbook

5 months ago

We can 100% accept SAFEs. We actually just opened fundraising; you can reach out at aaron@lanternbioworks.com or through our website, lanternbioworks.com

I think our odds are very good. I'm working with the original inventors, Drs. Hillman and Smith, who made it the first time.

I'm not sure that I can link to my Lightspeed application? The link they sent me is an edit link, and I don't want to post that on the public internet.